Current Research’s Projects

Project 1 – Multidisciplinary models for the development of personalized treatments: from surgery to functional genomics and CAR T cells

Project 2 – Identification of biomarkers for early diagnosis, characterization and monitoring of patients suffering from heart failure

Project 3 – “omic” approach to immune system disorders: definition of the biomolecular bases and consequent clinical implications related to diagnosis, treatment and prevention

Project 4 – Hereditary arrhythmogenic syndromes: etiology, diagnostic evaluation, interpretation of genetic causes, risk stratification and customization of interventions in patients with pathogenic variants

Project 5 – Role of the microbiota in alcohol addiction and alcohol-related disorders

Project 6 – Innovative biotechnology for the identification of new molecular targets for personalized treatments

Project 7 – Development of organoids from human tissues for studies of molecular and cellular mechanisms involved in human pathologies and in response to therapies

Project 8 – Study of prognostic markers and therapeutic response in neuroendocrine diseases

Project 9 – Extracellular signals in tissue degenerative pathologies: their relevance as predictive / prognostic factors and as potential innovative targets for treatments

Project 10 – Extracellular vesicles: new liquid biopsy tools to identify diagnostic and prognostic factors of disease in the new era of personalized medicine

Project 11 – Genomics and Proteomics in hematology

Project 12 – Prognostic factors and personalized treatments in lymphoproliferative diseases

Project 13 – Characterization of function’s and platelet count’s anomalies caused by genetic, iatrogenic, infectious factors and by acquired diseases for the personalized management of bleeding risk

Project 14 – Identification of biomarkers associated with advanced imaging techniques for early diagnosis, characterization and monitoring of patients with ischemic heart disease (acute and chronic) in order to identify specific therapeutic targets

Project 15 – Optimization and customization of the treatment of aortic and mitral valve disease: customization of the treatment of ventricular arrhythmias

Project 16 – Endotyping and precision medicine in bronchial asthma and in the fibrosis of chronic lung diseases

Project 17 – Characterization of Induced Pluripotent Stem Cells (iPS), from patients with Duchenne muscular dystrophy and advanced heart failure, as a personalized in vitro cellular model for functional studies and pharmacological tests: evolution towards precision medicine in dystrophic Cardiomyopathies

Project 18 – Biomarkers and new therapeutic approaches for neuropsychiatric diseases characterized by altered brain plasticity

Project 19 – Study of peripheral arterial disease. Study of pathogenetic mechanisms in animal experimental models and in clinical models. Evaluation of diagnostic biomarkers, severity and  progression of disease. Study of potential innovative management models and therapeutic targets

Project 20 – Identification of new disease-genes through the NGS method

Project 21 – Identification of biomarkers for personalized diabetes medicine, metabolic diseases and consequent cardiovascular and chronic complications

Project 22 – Biomolecular markers for the personalization of therapeutic strategy and prognosis of endocrine diseases

Project 23 – Study of radiological, tissue and circulating biomarkers in muscular dystrophies

Project 24 – Hemorrhagic risk in congenital, acquired and iatrogenic diseases of hematological interest: pathogenetic causes and optimization of therapeutic approaches for personalized management

Project 25 – Study of risk factors and identification of innovative therapies in Amyotrophic Lateral Sclerosis and in acquired and hereditary polyneuropathies

Project 26 – Autoimmune rheumatic diseases: rheumatoid arthritis, systemic erythematosus lupus and spondyloarthritis, a multiomic approach for personalized treatment

Project 1 – Applications of radiomics and techniques of quantitative analysis of bio-images for the creation and validation of clinical decision support systems, diagnostic tools, predictive models and prognostic stratification in patients with chronic diseases

Project 2 – Innovations in learning technologies in patients suffering from chronic diseases: advanced modeling applications, big data and distributed approaches in the creation of clinical Decision Support Systems and tools for Quality of Life assessment

Project 3 – Development and evaluation of innovative systems for the delivery of antimicrobial drugs

Project 4 – Treatment of complex patients’ acute and chronic infections: evaluation and repurposing of drugs with indirect antimicrobial action

Project 5 – Development of new diagnostic systems for infection’s monitoring in patients with complex pathology

Project 6 – Construction of a model to ensure durability and patient satisfaction in HIV positive subjects in antiretroviral treatment

Project 7 – Use of Sudoscan in the early diagnosis of Familial Amyloidosic Neuropathy and in the study of the involvement of “small” nerve fibers in various neuromuscular diseases

Project 8 – Application of quantitative imaging analysis techniques and Artificial Intelligence to PET / CT with 18F-FDG for a personalized approach to the diagnostic pathway, prediction of treatment response and prognostic stratification in patients with chronic and coplex diseases

Project 9 – Personalized Medicine of chronic liver diseases

Project 10 – Chronic progressive disorders of the liver with metabolic etiology, non-alcoholic and non-viral

Project 11 – Safety and efficacy of low molecular weight heparin therapy for the prevention of venous thromboembolic disease in hospitalized patients due to chronic inflammatory bowel disease during activity

Project 12 – Phenotypic, genetic and metabolic characterization of mitochondrial diseases

Project 13 – Clinical and molecular predictive and prognostic factors’ analysis and definition of the best therapeutic strategies in diseases of the genito-urinary district

Project 14 – Brain connectivity as a diagnostic and prognostic factor in degenerative diseases of the central nervous system

Project 15 – Microbiota and chronic urogenital disease: identification of microbial profiles for diagnostic, prognostic and predictive aims

Project 16 – Role of interventional radiology in the treatment of patients with primary or secondary hepatic lesions: optimization of procedures and patients’ selection, optimization of procedures and validation of new treatment algorithms

Project 17 – Gut-Liver Interaction in the Development of Liver Pathologies (GULIVER)

Project 18 – From the study of the pathogenetic mechanisms of chronic nose-sinus inflammation to the new diagnostic and therapeutic protocols of personalized medicine

Project 19 – Transplantation strategies and personalized cell therapies in the treatment of blood disorders

Project 20 – Personalized prophylaxis and treatment of infectious complications in blood disorders

Project 21 – Personalized prophylaxis and treatment of thrombotic complications in blood disorders

Project 22 – Intestinal microbiota transplantation

Project 23 – Alcohol use disorder: evaluation of intestinal microbiota, intake modalities, therapeutic implications and management of patients with and without alcoholic liver disease at various levels of severity

Project 24 – Role of interventional radiotherapy (brachytherapy) and metabolic radiotherapy in the treatment of patients with primitive or secondary tumor lesions: optimization of procedures, patients’ selection and validation of new therapeutic integration algorithms

Project 25 – Personalization and improvement of modern palliative radiotherapy for cancer patients

Project 26 – Personalization and improvement of modern Radiotherapy through treatments with hybrid equipment with magnetic resonance (Radiotherapy guided by MRI – MRIguidedRT-)

Project 27 – Optimization of radiotherapy treatment: innovative technologies, splits and targeting

Project 28 – Identification, validation and “real-life” implementation of prognostic (clinical, instrumental and laboratory) or predictors of therapy response markers in patients with Multiple Sclerosis and other CNS

Project 29 – B-mediated autoimmunity in idiopathic inflammatory myopathies: prevalence and diagnostic and prognostic value of myositis-specific autoantibodies (MSA) and anti-CN1A antibodies. Circulating serum microRNAs in the inclusion body myositis (s-IBM)

Project 30 – Immunotherapy in allergies

Project 31 – Identification of serum and tissue biomarkers with prognostic and predictive value and identification of efficacy of molecular and immunotherapeutic drugs in chronic lung cancer

Project 32 – Assessment and characterization of chronic pain conditions and headaches: study of biomarkers predictive of response to new drug treatments

Project 33 – Management and treatment of status epilepticus: optimization of a diagnostic-therapeutic algorithm

Project 34 – Use of muscular RM in neuromuscular diseases

Project 35 – Study of immunological and genetic factors and validation of innovative therapeutic strategies in melanocytic diseases of the ocular district

Project 36 – Real-life implementation studies of biomarkers and / or integrated models to assess their effectiveness in the treatment of chronic intestinal inflammatory diseases

Project 37 – The microbiota as a tool for personalized medicine for diagnosis, prognosis and therapy of gastroenterological diseases

Project 38 – Development and identification of possible prognostic factors; assessment of the impact of medical and supportive therapies in the context of complex chronic diseases affecting the gastro-intestinal tract

Project 1 – Definition and development of “patient-centered analytics” for monitoring clinical care pathways

Project 2 – Etiological epidemiology of chronic diseases: identification of risk factors for a personalized prevention

Project 3 – Genetic epidemiology of chronic diseases

Project 4 – Support for the definition of health policies in the personalized medicine sector with particular reference to innovative prevention tools

Project 5 – Definition and implementation of tools for the literacy of health professionals and citizens in the field of personalized medicine rofessionisti sanitari e dei cittadini nel settore della medicina personalizzata

Project 6 – Environmental surveillance aimed at the safety of patients and operators

Project 7 – Innovative tools for personalized risk prevention, health promotion and functional recovery in workplaces

Project 8 – Evaluation of innovative interventions for chronicity management

Project 9 – Evaluation of the clinical and economic-organizational impact of the introduction of rapid molecular methods for the diagnosis of invasive infections

Project 1 – Electrophysiological and molecular biomarkers for early diagnosis and development of innovative therapies for Alzheimer’s disease

Project 2 – Impact of Hypoacusis on cognitive decline in the elderly

Project 3 – Innovations in the active management of complexity and performance in fragile elderly patients suffering from chronic diseases, with particular focus on elderly cancer patients: applications of support therapies, clinical decision making, tools for quality of life assessment

Project 4 – Multi-morbidity: identification of disease clusters through clinical and biological markers and definition of health care pathways

Project 5 – Identification of clinical, biological and personal factors associated with the development of frailty and sarcopenia

Project 6 – Personalized adult medicine with genetic syndromes characterized by premature aging

Project 7 – Personalized nutritional approaches for the fragile, sarcopenic and multi-soft elderly subject

Project 8 – COMMAS (Connectivity and Motor Recovery Monitoring in Acute ischemic Stroke): Correlation between the spontaneous movement of the paretic limbs and the changes in cortical connectivity in ischemic stroke. A multiparametric approach for the creation of a predictive model of prognosis and for a definition of a tele-rehabilitation protocol

Project 1 – Development of a new gallbladder prosthesis for the prevention of gallbladder stone migration, cholecystitis and cholangitis prevention

Project 2 – Development of new minimally invasive endoscopic procedures for the treatment of morbid obesity and choice of the ideal patient based on the mapping of gastric and colic microbiota

Project 3 – Implementation of minimally invasive surgery in the complex chronic pathology of the digestive system

Project 4 – Glioblastoma stem cell transplantation in autologous cerebral organoids: development of an innovative medical-surgical device to test personalized treatments against glioblastoma

Project 5 – Pleuro-pulmonary ultrasonology: basic deepenings and future developments

Project 6 – Development of advanced spectroscopic and microscopic technologies for the early diagnosis of disease

Project 7 – Nanostructural Materials for Biotechnology and Nanomedicine

Project 8 – Development and innovation of new devices in Robotic Surgery

Project 9 – Image analysis systems based on deep learning techniques implemented in neural networks with functionalities supporting the clinical decision

Project 10 – Development and utility of innovative biotechnologies of magnetic resonance (tractography with diffusion tensors) to preserve periprostatic nerve fibers in patients with operated and / or radiotreated prostate cancer

Project 11 – Development and clinical test of a completely implanted bi-directional bionic prosthesis

Project 12 – Neurophysiology and ultrasound in peripheral nervous system diseases: relationship between function and morphology

Project 13 – Multisensory stimulation: study on the influence of contents and degree of immersiveness in the responses of the nervous system of the healthy subject and of the patient suffering from acquired diseases of the Central Nervous System

Project 14 – Development of minimally invasive techniques in thoracic surgery in cancer and non-cancer research

Project 1 – Innovative and personalized approaches for the diagnosis and the treatment of obstetric failure

Project 2 – Regenerative medicine approaches: from in vitro studies to preclinical models toward clinical trials

Project 3 – Translational medicine of sexually transmitted infections (STDs) in women of childbearing age and during pregnancy. Construction of a flexible and exportable model

Project 4 – Neurodevelopmental disorders: innovative models for clinical-genetic diagnosis and translational research through the study of disease mechanisms for potential therapeutic approaches

Project 5 – Multidisciplinary approach to the diagnosis and to therapeutic management of monogenic autoinflammatory syndromes in children

Project 6 – Definition of the biomolecular bases and of the clinical implications related to diagnosis, therapy and prevention of childhood vasculitic syndromes

Project 7 – Development and identification of biomarkers for prevention, diagnosis, characterization and prognosis of complex female chronic diseases

Project 8 – Development of integrated multi-parameter models for the prediction of clinical progress and responsiveness to standard and / or innovative pharmacological treatments in women with complex chronic diseases

Project 9 – Real-life implementation studies of biomarkers and / or integrated models to assess their effectiveness in women with complex chronic diseases

Project 10 – Real-life implementation studies of precision therapeutic strategies to assess their effectiveness and sustainability in the women’s with complex chronic diseases quality of life

Project 11 – Implementation of innovative biotechnologies in the integrated surgical treatment of gynecological diseases and their evaluation in terms of effectiveness and sustainability

Project 12 – Development of multi-parameter integrated models (clinical, biochemical, biophysical parameters) for screening, early diagnosis, response to therapies and obstetric outcome in women suffering from pathologies which complicate pregnancy, childbirth and / or puerperium

Project 13 – Real-life implementation studies of integrated predictive models of obstetric outcomes to assess their effectiveness in women with physiological pregnancy or at-risk pregnancy during gestation, childbirth and puerperium

Project 14 – Development of integrated models useful for clinical support in the prediction of clinical progress and responsiveness to standard and / or innovative pharmacological treatments in children with complex chronic diseases

Project 15 – Real-life implementation studies of biomarkers and / or integrated models to assess the effectiveness of new therapeutic strategies in children with complex chronic diseases

Project 16 – Role of ultrasonology in the management of respiratory diseases of children and women during gestational age

Project 17 – Identification of cancer- and microenvironment-specific biomarkers and development of innovative molecular-target drugs in chronic breast cancer

Project 1 – Development of innovative strategies for the management of multi-organic insufficiency of the preterm infant

Project 2 – Integrated diagnostic-therapeutic approach for the management of serious infections, particularly in fragile patients

Project 3 – Epidemiology, risk factors and innovative therapies in the management of acute and chronic infections

Project 4 – Development and validation of new diagnostic systems for the management of acute and chronic infections

Project 5 – Molecular and functional genotypic and phenotypic characterization of microorganisms of medical interest for the development of personalized therapies

Project 6 – Innovative Biotechnology for Laboratory Diagnostics

Project 7 – Risk factors and laboratory tests for the early diagnosis and for the management of serious fungal infections

Project 8 – Predictive factors of outcome and clinical impact on patients subjected to general anesthesia: influence of anesthetic techniques and perioperative management

Project 9 – Individualization of advanced respiratory support for patients with respiratory failure, cardiac arrest and under general anesthesia

Project 10 – Nerve Growth Factor in Children with acute trauma

Project 11 – Sedation with Alfa2-agonists in Intensive Care

Project 12 – Effectiveness and safety in wall blocks for postoperative pain control