Each research line carries out numerous scientific projects for Current Research. The following are the projects reported for the year 2018.
Line 1
Translational Research in Personalized Medicine of Complex Chronic Diseases
Line Manager:
Line 1 Projects
Project 1 – Multidisciplinary models for the development of personalized treatments: from surgery to functional genomics and CAR T cells
Project 2 – Identification of biomarkers for early diagnosis, characterization and monitoring of patients suffering from heart failure
Project 3 – “omic” approach to immune system disorders: definition of the biomolecular bases and consequent clinical implications related to diagnosis, treatment and prevention
Project 4 – Hereditary arrhythmogenic syndromes: etiology, diagnostic evaluation, interpretation of genetic causes, risk stratification and customization of interventions in patients with pathogenic variants
Project 5 – Role of the microbiota in alcohol addiction and alcohol-related disorders
Project 6 – Innovative biotechnology for the identification of new molecular targets for personalized treatments
Project 7 – Development of organoids from human tissues for studies of molecular and cellular mechanisms involved in human pathologies and in response to therapies
Project 8 – Study of prognostic markers and therapeutic response in neuroendocrine diseases
Project 9 – Extracellular signals in tissue degenerative pathologies: their relevance as predictive / prognostic factors and as potential innovative targets for treatments
Project 10 – Extracellular vesicles: new liquid biopsy tools to identify diagnostic and prognostic factors of disease in the new era of personalized medicine
Project 11 – Genomics and Proteomics in hematology
Project 12 – Prognostic factors and personalized treatments in lymphoproliferative diseases
Project 13 – Characterization of function’s and platelet count’s anomalies caused by genetic, iatrogenic, infectious factors and by acquired diseases for the personalized management of bleeding risk
Project 14 – Identification of biomarkers associated with advanced imaging techniques for early diagnosis, characterization and monitoring of patients with ischemic heart disease (acute and chronic) in order to identify specific therapeutic targets
Project 15 – Optimization and customization of the treatment of aortic and mitral valve disease: customization of the treatment of ventricular arrhythmias
Project 16 – Endotyping and precision medicine in bronchial asthma and in the fibrosis of chronic lung diseases
Project 17 – Characterization of Induced Pluripotent Stem Cells (iPS), from patients with Duchenne muscular dystrophy and advanced heart failure, as a personalized in vitro cellular model for functional studies and pharmacological tests: evolution towards precision medicine in dystrophic Cardiomyopathies
Project 18 – Biomarkers and new therapeutic approaches for neuropsychiatric diseases characterized by altered brain plasticity
Project 19 – Study of peripheral arterial disease. Study of pathogenetic mechanisms in animal experimental models and in clinical models. Evaluation of diagnostic biomarkers, severity and progression of disease. Study of potential innovative management models and therapeutic targets
Project 20 – Identification of new disease-genes through the NGS method
Project 21 – Identification of biomarkers for personalized diabetes medicine, metabolic diseases and consequent cardiovascular and chronic complications
Project 22 – Biomolecular markers for the personalization of therapeutic strategy and prognosis of endocrine diseases
Project 23 – Study of radiological, tissue and circulating biomarkers in muscular dystrophies
Project 24 – Hemorrhagic risk in congenital, acquired and iatrogenic diseases of hematological interest: pathogenetic causes and optimization of therapeutic approaches for personalized management
Project 25 – Study of risk factors and identification of innovative therapies in Amyotrophic Lateral Sclerosis and in acquired and hereditary polyneuropathies
Project 26 – Autoimmune rheumatic diseases: rheumatoid arthritis, systemic erythematosus lupus and spondyloarthritis, a multiomic approach for personalized treatment
Line 2
Clinical Research in Personalized Medicine of complex and chronic diseases
Manager:
Line 2 Projects
Project 1 – Applications of radiomics and techniques of quantitative analysis of bio-images for the creation and validation of clinical decision support systems, diagnostic tools, predictive models and prognostic stratification in patients with chronic diseases
Project 2 – Innovations in learning technologies in patients suffering from chronic diseases: advanced modeling applications, big data and distributed approaches in the creation of clinical Decision Support Systems and tools for Quality of Life assessment
Project 3 – Development and evaluation of innovative systems for the delivery of antimicrobial drugs
Project 4 – Treatment of complex patients’ acute and chronic infections: evaluation and repurposing of drugs with indirect antimicrobial action
Project 5 – Development of new diagnostic systems for infection’s monitoring in patients with complex pathology
Project 6 – Construction of a model to ensure durability and patient satisfaction in HIV positive subjects in antiretroviral treatment
Project 7 – Use of Sudoscan in the early diagnosis of Familial Amyloidosic Neuropathy and in the study of the involvement of “small” nerve fibers in various neuromuscular diseases
Project 8 – Application of quantitative imaging analysis techniques and Artificial Intelligence to PET / CT with 18F-FDG for a personalized approach to the diagnostic pathway, prediction of treatment response and prognostic stratification in patients with chronic and coplex diseases
Project 9 – Personalized Medicine of chronic liver diseases
Project 10 – Chronic progressive disorders of the liver with metabolic etiology, non-alcoholic and non-viral
Project 11 – Safety and efficacy of low molecular weight heparin therapy for the prevention of venous thromboembolic disease in hospitalized patients due to chronic inflammatory bowel disease during activity
Project 12 – Phenotypic, genetic and metabolic characterization of mitochondrial diseases
Project 13 – Clinical and molecular predictive and prognostic factors’ analysis and definition of the best therapeutic strategies in diseases of the genito-urinary district
Project 14 – Brain connectivity as a diagnostic and prognostic factor in degenerative diseases of the central nervous system
Project 15 – Microbiota and chronic urogenital disease: identification of microbial profiles for diagnostic, prognostic and predictive aims
Project 16 – Role of interventional radiology in the treatment of patients with primary or secondary hepatic lesions: optimization of procedures and patients’ selection, optimization of procedures and validation of new treatment algorithms
Project 17 – Gut-Liver Interaction in the Development of Liver Pathologies (GULIVER)
Project 18 – From the study of the pathogenetic mechanisms of chronic nose-sinus inflammation to the new diagnostic and therapeutic protocols of personalized medicine
Project 19 – Transplantation strategies and personalized cell therapies in the treatment of blood disorders
Project 20 – Personalized prophylaxis and treatment of infectious complications in blood disorders
Project 21 – Personalized prophylaxis and treatment of thrombotic complications in blood disorders
Project 22 – Intestinal microbiota transplantation
Project 23 – Alcohol use disorder: evaluation of intestinal microbiota, intake modalities, therapeutic implications and management of patients with and without alcoholic liver disease at various levels of severity
Project 24 – Role of interventional radiotherapy (brachytherapy) and metabolic radiotherapy in the treatment of patients with primitive or secondary tumor lesions: optimization of procedures, patients’ selection and validation of new therapeutic integration algorithms
Project 25 – Personalization and improvement of modern palliative radiotherapy for cancer patients
Project 26 – Personalization and improvement of modern Radiotherapy through treatments with hybrid equipment with magnetic resonance (Radiotherapy guided by MRI – MRIguidedRT-)
Project 27 – Optimization of radiotherapy treatment: innovative technologies, splits and targeting
Project 28 – Identification, validation and “real-life” implementation of prognostic (clinical, instrumental and laboratory) or predictors of therapy response markers in patients with Multiple Sclerosis and other CNS
Project 29 – B-mediated autoimmunity in idiopathic inflammatory myopathies: prevalence and diagnostic and prognostic value of myositis-specific autoantibodies (MSA) and anti-CN1A antibodies. Circulating serum microRNAs in the inclusion body myositis (s-IBM)
Project 30 – Immunotherapy in allergies
Project 31 – Identification of serum and tissue biomarkers with prognostic and predictive value and identification of efficacy of molecular and immunotherapeutic drugs in chronic lung cancer
Project 32 – Assessment and characterization of chronic pain conditions and headaches: study of biomarkers predictive of response to new drug treatments
Project 33 – Management and treatment of status epilepticus: optimization of a diagnostic-therapeutic algorithm
Project 34 – Use of muscular RM in neuromuscular diseases
Project 35 – Study of immunological and genetic factors and validation of innovative therapeutic strategies in melanocytic diseases of the ocular district
Project 36 – Real-life implementation studies of biomarkers and / or integrated models to assess their effectiveness in the treatment of chronic intestinal inflammatory diseases
Project 37 – The microbiota as a tool for personalized medicine for diagnosis, prognosis and therapy of gastroenterological diseases
Project 38 – Development and identification of possible prognostic factors; assessment of the impact of medical and supportive therapies in the context of complex chronic diseases affecting the gastro-intestinal tract
Line 3
Sustainability of Personalized and Predictive Medicine in the National Health System
Manager:
Line 3 Projects
Project 1 – Definition and development of “patient-centered analytics” for monitoring clinical care pathways
Project 2 – Etiological epidemiology of chronic diseases: identification of risk factors for a personalized prevention
Project 3 – Genetic epidemiology of chronic diseases
Project 4 – Support for the definition of health policies in the personalized medicine sector with particular reference to innovative prevention tools
Project 5 – Definition and implementation of tools for the literacy of health professionals and citizens in the field of personalized medicine rofessionisti sanitari e dei cittadini nel settore della medicina personalizzata
Project 6 – Environmental surveillance aimed at the safety of patients and operators
Project 7 – Innovative tools for personalized risk prevention, health promotion and functional recovery in workplaces
Project 8 – Evaluation of innovative interventions for chronicity management
Project 9 – Evaluation of the clinical and economic-organizational impact of the introduction of rapid molecular methods for the diagnosis of invasive infections
Line 4
Innovative and predictive approaches in elderly patients
Manager:
Line 4 Projects
Project 1 – Electrophysiological and molecular biomarkers for early diagnosis and development of innovative therapies for Alzheimer’s disease
Project 2 – Impact of Hypoacusis on cognitive decline in the elderly
Project 3 – Innovations in the active management of complexity and performance in fragile elderly patients suffering from chronic diseases, with particular focus on elderly cancer patients: applications of support therapies, clinical decision making, tools for quality of life assessment
Project 4 – Multi-morbidity: identification of disease clusters through clinical and biological markers and definition of health care pathways
Project 5 – Identification of clinical, biological and personal factors associated with the development of frailty and sarcopenia
Project 6 – Personalized adult medicine with genetic syndromes characterized by premature aging
Project 7 – Personalized nutritional approaches for the fragile, sarcopenic and multi-soft elderly subject
Project 8 – COMMAS (Connectivity and Motor Recovery Monitoring in Acute ischemic Stroke): Correlation between the spontaneous movement of the paretic limbs and the changes in cortical connectivity in ischemic stroke. A multiparametric approach for the creation of a predictive model of prognosis and for a definition of a tele-rehabilitation protocol
Line 5
New frontiers of innovation in health technologies and development of medical surgical devices
Manager:
Line 5 Projects
Project 1 – Development of a new gallbladder prosthesis for the prevention of gallbladder stone migration, cholecystitis and cholangitis prevention
Project 2 – Development of new minimally invasive endoscopic procedures for the treatment of morbid obesity and choice of the ideal patient based on the mapping of gastric and colic microbiota
Project 3 – Implementation of minimally invasive surgery in the complex chronic pathology of the digestive system
Project 4 – Glioblastoma stem cell transplantation in autologous cerebral organoids: development of an innovative medical-surgical device to test personalized treatments against glioblastoma
Project 5 – Pleuro-pulmonary ultrasonology: basic deepenings and future developments
Project 6 – Development of advanced spectroscopic and microscopic technologies for the early diagnosis of disease
Project 7 – Nanostructural Materials for Biotechnology and Nanomedicine
Project 8 – Development and innovation of new devices in Robotic Surgery
Project 9 – Image analysis systems based on deep learning techniques implemented in neural networks with functionalities supporting the clinical decision
Project 10 – Development and utility of innovative biotechnologies of magnetic resonance (tractography with diffusion tensors) to preserve periprostatic nerve fibers in patients with operated and / or radiotreated prostate cancer
Project 11 – Development and clinical test of a completely implanted bi-directional bionic prosthesis
Project 12 – Neurophysiology and ultrasound in peripheral nervous system diseases: relationship between function and morphology
Project 13 – Multisensory stimulation: study on the influence of contents and degree of immersiveness in the responses of the nervous system of the healthy subject and of the patient suffering from acquired diseases of the Central Nervous System
Project 14 – Development of minimally invasive techniques in thoracic surgery in cancer and non-cancer research
Line 6
Approcci innovativi e personalizzati nella scienza della salute della donna e del bambino
Manager:
Line 6 Projects
Project 1 – Innovative and personalized approaches for the diagnosis and the treatment of obstetric failure
Project 2 – Regenerative medicine approaches: from in vitro studies to preclinical models toward clinical trials
Project 3 – Translational medicine of sexually transmitted infections (STDs) in women of childbearing age and during pregnancy. Construction of a flexible and exportable model
Project 4 – Neurodevelopmental disorders: innovative models for clinical-genetic diagnosis and translational research through the study of disease mechanisms for potential therapeutic approaches
Project 5 – Multidisciplinary approach to the diagnosis and to therapeutic management of monogenic autoinflammatory syndromes in children
Project 6 – Definition of the biomolecular bases and of the clinical implications related to diagnosis, therapy and prevention of childhood vasculitic syndromes
Project 7 – Development and identification of biomarkers for prevention, diagnosis, characterization and prognosis of complex female chronic diseases
Project 8 – Development of integrated multi-parameter models for the prediction of clinical progress and responsiveness to standard and / or innovative pharmacological treatments in women with complex chronic diseases
Project 9 – Real-life implementation studies of biomarkers and / or integrated models to assess their effectiveness in women with complex chronic diseases
Project 10 – Real-life implementation studies of precision therapeutic strategies to assess their effectiveness and sustainability in the women’s with complex chronic diseases quality of life
Project 11 – Implementation of innovative biotechnologies in the integrated surgical treatment of gynecological diseases and their evaluation in terms of effectiveness and sustainability
Project 12 – Development of multi-parameter integrated models (clinical, biochemical, biophysical parameters) for screening, early diagnosis, response to therapies and obstetric outcome in women suffering from pathologies which complicate pregnancy, childbirth and / or puerperium
Project 13 – Real-life implementation studies of integrated predictive models of obstetric outcomes to assess their effectiveness in women with physiological pregnancy or at-risk pregnancy during gestation, childbirth and puerperium
Project 14 – Development of integrated models useful for clinical support in the prediction of clinical progress and responsiveness to standard and / or innovative pharmacological treatments in children with complex chronic diseases
Project 15 – Real-life implementation studies of biomarkers and / or integrated models to assess the effectiveness of new therapeutic strategies in children with complex chronic diseases
Project 16 – Role of ultrasonology in the management of respiratory diseases of children and women during gestational age
Project 17 – Identification of cancer- and microenvironment-specific biomarkers and development of innovative molecular-target drugs in chronic breast cancer
Line 7
Innovative biotechnologies and diagnostic and intensive therapy personalization paths for acute pathologies
Manager:
Line 7 Projects
Project 1 – Development of innovative strategies for the management of multi-organic insufficiency of the preterm infant
Project 2 – Integrated diagnostic-therapeutic approach for the management of serious infections, particularly in fragile patients
Project 3 – Epidemiology, risk factors and innovative therapies in the management of acute and chronic infections
Project 4 – Development and validation of new diagnostic systems for the management of acute and chronic infections
Project 5 – Molecular and functional genotypic and phenotypic characterization of microorganisms of medical interest for the development of personalized therapies
Project 6 – Innovative Biotechnology for Laboratory Diagnostics
Project 7 – Risk factors and laboratory tests for the early diagnosis and for the management of serious fungal infections
Project 8 – Predictive factors of outcome and clinical impact on patients subjected to general anesthesia: influence of anesthetic techniques and perioperative management
Project 9 – Individualization of advanced respiratory support for patients with respiratory failure, cardiac arrest and under general anesthesia
Project 10 – Nerve Growth Factor in Children with acute trauma
Project 11 – Sedation with Alfa2-agonists in Intensive Care
Project 12 – Effectiveness and safety in wall blocks for postoperative pain control